Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha

Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha (ERα)

P-195: Thymoquinone Increases Efficacy of Tamoxifen Induced Apoptosis in Human Breast Cancer MCF-7 Cells: In Vitro

Background: The objective of this study is to evaluate combined effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MCF-7 cells (Noninvasive human breast cancer cell line, estrogen receptor positive). Materials and Methods: The human breast cancer MCF- 7 cells were treated with Tamoxifen (2 μM) alone or in combination with Th...

Comparative Study of Simultaneously and Interval Injection Estradiol and Tamoxifen on Estrogen Receptor α Expression in the Ca 1 Region of Hippocampal Pyramidal Neurons in Ovariectomized Rat

Purpose: The aim of our study is the assesment of estrogen receptor a expression in pyramidal neurons in rat CA 1hippocampus that has been ovariectomized. By using the estrogen antagonist, Tamoxifen level of expression of estrogen receptor a in these cells. Materials and Methods: To study the effect of 17- b estradiol and tamoxifen on estrogen receptors a, expression in hippocampus rats of Wist...

The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

ADENOSINE DEAMINASE ACTIVITY IN ESTROGEN RECEPTOR POSITIVE AND NEGATIVE HUMAN BREAST CANCER CELL LINES

 ABSTRACT Background: The aims of this study were to assay the activity of adenosine deaminase (ADA) in estrogen receptor positive (MCF-7) and negative (MDA-MB468) breast cancer cell lines. Methods: MDA-MB468 and MCF-7 breast cancer cell lines were cultured in complete medium, striped serum with and without 0.0 1~-LM diethylstilbestrol (DES), complete medium in the presence and absence of 111M ...